Entity Metadata

• Generic Name: Tylosin Phosphate
• Trade Names: Tylan
• Active Ingredient: Tylosin A (>80%), tylosin B (desmycosin), tylosin C (macrocin), and tylosin D (relomycin)
• Drug Class: Antimicrobial > Macrolide
• Commercial Importance: High
• India Relevance: 5 day withdrawal
• Status: Permitted (subject to statutory withdrawal period)

Identity

Tylosin Phosphate is an active therapeutic medicine and 16-member lactone ring macrolide antibiotic used within the poultry sector to target specific bacterial pathogens.

Overview

Tylosin Phosphate is a high-priority therapeutic antimicrobial used in the Indian poultry industry. Produced through the fermentation of Streptomyces fradiae, it is a primary therapeutic agent specifically indicated for the treatment of Mycoplasmosis targeting Mycoplasma species and Chronic Respiratory Disease (CRD). It is highly lipophilic and achieves high concentrations in the respiratory epithelium and macrophages. Its bioavailability is highly vulnerable to dietary interactions, specifically adsorption onto certain feed additives.

Structured Facts

Indications

Mycoplasmosis, Mycoplasma gallisepticum, Chronic Respiratory Disease (CRD), and infectious sinusitis in turkeys.

Mechanism of Action

The molecule acts by binding reversibly to the 23S rRNA of the 50S ribosomal subunit, physically blocking the translocation step of bacterial protein synthesis.

Dosage

Water: 2 g/gal drinking water; IM: 5 mg/kg bw/day.

Administration Route

Water; Intramuscular (IM).

Duration

Water: 2 to 8 days.

Withdrawal Period

5 Days (India standard); Eggs: 2 days (extra-label).

Quantitative Data

• Dose: 2 g/gal (water); 5 mg/kg bw/day (IM)
• Concentration: Premix: 50-250 g/kg tylosin activity
• Withdrawal: 5 Days

Relationships

• Target Diseases: Mycoplasmosis (Mycoplasma species), CRD, infectious sinusitis
• Feed Additives: Bentonite, biochar, and certain mycotoxin binders adsorb the drug, reducing systemic absorption.
• Drug Interactions: Adsorbs to bentonite, reducing absorption.
• Resistance: Sub-therapeutic use can select for resistant zoonotic pathogens like Campylobacter spp. and Enterococcus spp..

Evidence

• Source: India Poultry Knowledge Inventory, India Poultry Knowledge Inventory and Master Management Guide, Poultry Disease and Health Management Compendium, Comprehensive Guide to Avian Pathogens and Poultry Health Management, Poultry Medicine Research Plan
• Evidence Strength: High

References

• Comprehensive Guide to Avian Pathogens and Poultry Health Management
• India Poultry Knowledge Inventory
• India Poultry Knowledge Inventory and Master Management Guide
• Poultry Disease and Health Management Compendium
• Poultry Medicine Research Plan

Missing Information

Exact chemical formula, adverse effects, storage conditions, precise page numbers.

Schema Coverage

Identity: Complete Structured Facts: Partial Quantitative Data: Partial Relationships: Complete Evidence: Partial References: Complete Overall Completeness: 75%