Identity

Bacitracin Methylene Disalicylate is an active therapeutic medicine and antibacterial growth promoter (AGP) used within the poultry sector.

Overview

Bacitracin Methylene Disalicylate is a high-priority therapeutic antimicrobial used in the Indian poultry industry. It is specifically utilized for targeting enteric bacteria and acts as a feed-grade growth promoter, holding significant commercial importance due to its ability to prevent clinical outbreaks of necrotic enteritis while improving the feed conversion ratio (FCR) of commercial broilers. Because of its high molecular weight and ionic charge, it is not absorbed from the avian gastrointestinal tract, confining its bactericidal action to the intestinal lumen. It exhibits complete stability in feed manufacturing and pelleting and is highly compatible with live oocyst coccidiosis vaccines.

Structured Facts

Indications

Enteric Bacteria, Necrotic Enteritis (Clostridium perfringens), Streptococcus spp., Staphylococcus spp., Actinomyces, and Fusobacterium.

Mechanism of Action

It functions by binding tightly to divalent metal ions, thereby inhibiting the dephosphorylation of C55-isoprenyl pyrophosphate (bactoprenol pyrophosphate). This blocks the lipid carrier from transporting peptidoglycan monomer subunits across the cytoplasmic membrane, halting bacterial cell wall synthesis.

Dosage

25-50 g/ton (monotherapy); 30 g/ton (with Nicarbazin).

Administration Route

Feed.

Withdrawal Period

0 days (monotherapy); 4 days (when combined with Nicarbazin).

Contraindications

Avoid combining with other systemically active polypeptides.

Quantitative Data

• Dose: 25-50 g/ton (monotherapy); 30 g/ton (with Nicarbazin)
• Concentration: Premix: BMD 10, 25, 30, 40, 50, 60, or 12
• Withdrawal: 0 days (monotherapy); 4 days (with Nicarbazin)

Relationships

• Target Diseases: Necrotic Enteritis, Enteric Bacteria
• Related Medicines: Nicarbazin
• Vaccines: Highly compatible with live oocyst coccidiosis vaccines (such as Coccivac-B)
• Drug Interactions: Avoid combining with other systemically active polypeptides