Identity

Amoxicillin Trihydrate is an active therapeutic medicine and a broad-spectrum, semi-synthetic aminopenicillin antibiotic used within the poultry sector.

Overview

Amoxicillin Trihydrate is a high-priority therapeutic antimicrobial used in the Indian poultry industry. It is specifically indicated for the treatment of Systemic Septicemia, soft tissue infections, and necrotic enteritis. It relies on functional, intact mucosal membranes for active transport and passive diffusion. To ensure compliance with food safety and regulatory standards, its administration requires a statutory withdrawal period of 5 days.

Structured Facts

Indications

Systemic Septicemia, soft tissue infections, necrotic enteritis, secondary bacterial infections following predator attacks. Highly effective against penicillin-sensitive Gram-positive bacteria (Streptococci, Staphylococci, Clostridia) and key Gram-negative pathogens (E. coli, Salmonella spp., and Pasteurella multocida).

Mechanism of Action

Bactericidal; functions through the inhibition of transpeptidase enzymes (penicillin-binding proteins, or PBPs) responsible for cross-linking peptidoglycan polymers in the bacterial cell wall. This weakens the cell wall, causing osmotic lysis.

Dosage

55-200 mg/kg body weight or 200-1500 mg/L water.

Administration Route

Water.

Withdrawal Period

5 Days (India relevance); Meat: 1 to 3 days; Eggs: 1 day.

Quantitative Data

• Dose: 55-200 mg/kg body weight or 200-1500 mg/L water
• Concentration: Soluble Powder: 50%-80% w/w amoxicillin trihydrate
• Withdrawal: 5 Days

Relationships

• Target Diseases: Systemic Septicemia, necrotic enteritis, soft tissue infections
• Drug Interactions: Concurrent Eimeria infection (Coccidiosis) causes enteric mucosal damage, significantly impairing drug absorption and leading to marked reduction in maximum plasma concentration (Cmax), AUC, and overall oral bioavailability, which may require dose adjustment.