Tiamulin Hydrogen Fumarate
Tiamulin Hydrogen Fumarate
Identity
Tiamulin Hydrogen Fumarate is an active therapeutic medicine and semi-synthetic pleuromutilin antibiotic used within the poultry sector to target specific bacterial pathogens.
Overview
Tiamulin Hydrogen Fumarate is a high-priority therapeutic antimicrobial used in the Indian poultry industry. It is highly effective against mycoplasmas and specifically indicated for the treatment of Mycoplasmosis and infectious synovitis. To ensure compliance with food safety standards, its administration requires a statutory withdrawal period of 3 days. It presents a critical pharmacological risk due to its potent inhibition of hepatic enzymes, leading to lethal interactions with specific coccidiostats.
Structured Facts
Indications
Mycoplasmosis (Mycoplasma gallisepticum, Mycoplasma synoviae), infectious synovitis, Gram-positive anaerobic bacteria.
Mechanism of Action
Tiamulin binds to the peptidyl transferase center of the 50S ribosomal subunit, physically obstructing the proper positioning of aminoacyl-tRNA and preventing peptide bond formation.
Dosage
10-25 mg/kg bw/day.
Administration Route
Water.
Duration
3 to 5 days.
Withdrawal Period
3 Days.
Contraindications
Must not be administered within 7 days of feeding ionophore-medicated diets.
Adverse Effects
Exhibits a severe, often fatal interaction with polyether ionophore coccidiostats, leading to severe necrosis of skeletal and myocardial muscle fibers.
Quantitative Data
- Dose: 10-25 mg/kg bw/day
- Concentration: Soluble Powder: 45%-80% active tiamulin hf
- Withdrawal: 3 Days
Relationships
- Target Diseases: Mycoplasmosis (Mycoplasma species), infectious synovitis
- Related Medicines: Synergistic interaction with tetracyclines (such as chlortetracycline) allows lower therapeutic doses. Lethal interaction with polyether ionophores (monensin, narasin, maduramicin, salinomycin).
- Drug Interactions: Potent inhibitor of the hepatic Cytochrome P450 3A (CYP3A) enzyme superfamily; blocks oxidative metabolism of ionophores causing them to accumulate to toxic levels.