Identity

Maduramicin Ammonium is an active therapeutic medicine and highly potent polyether ionophore used within the poultry sector to target specific parasitic infections.

Overview

Maduramicin Ammonium is a critical therapeutic anticoccidial used in the Indian poultry industry. Produced by Actinomadura yumaensis, it is specifically indicated for the prevention and treatment of Coccidiosis, targeting the early asexual stages of Eimeria species. To ensure compliance with food safety and regulatory standards, its administration requires a statutory withdrawal period of 5 days. Due to its high potency, it carries an elevated risk of accidental toxicosis from mixing errors in feed mills.

Structured Facts

Indications

Coccidiosis, Eimeria species (E. tenella, E. maxima, E. acervulina, E. necatrix).

Mechanism of Action

Operates by disrupting transmembrane electrochemical gradients and monovalent ion transport, showing efficacy at significantly lower concentrations than other ionophores.

Dosage

5 g/ton (5 ppm) in complete feed.

Administration Route

Feed.

Withdrawal Period

5 Days.

Contraindications

Poor tolerance in non-target animals, particularly equines, calves, and rabbits.

Adverse Effects

Acute clinical toxicity characterized by myocardial lesions, congested visceral organs, rapid cardiotoxicity, and high mortality.

Quantitative Data

• Dose: 5 g/ton (5 ppm)
• Withdrawal: 5 Days

Relationships

• Target Diseases: Coccidiosis (Eimeria species).
• Related Medicines: Monensin Sodium, Narasin.
• Drug Interactions: Extremely narrow safety margin requiring strict milling limits (0.05 mg/kg carryover maximum) to prevent accidental poisoning.