Identity

Diclazuril is an active therapeutic chemical synthetic medicine used within the poultry sector to target specific parasitic infections.

Overview

Diclazuril is a high-priority chemical synthetic anticoccidial used in the Indian poultry industry. It is a benzeneacetonitrile-class coccidiostat specifically indicated for the prevention and treatment of Coccidiosis, targeting Eimeria species. Due to its pharmacological profile, its administration allows for a zero-day statutory withdrawal period. It is highly tolerated but continuous use can select for resistant populations, making it a key component of rotation programs.

Structured Facts

Indications

Coccidiosis, Eimeria species (E. tenella, E. acervulina, E. maxima, E. necatrix, E. brunetti).

Mechanism of Action

Targets specific intracellular stages of the Eimeria life cycle, arresting the development of extracellular sporozoites and developing merozoites without transporting ions.

Dosage

1 g/ton (1 ppm) in complete feed.

Administration Route

Feed.

Withdrawal Period

0 Days (Zero-day withdrawal).

Contraindications

Not specified for poultry flocks (highly tolerated), though non-target carryover limits exist for laying birds.

Adverse Effects

Can alter the pharmacokinetics and elimination rates of systemically active tetracyclines, leading to slower excretion. Continuous monotherapy can select for resistant coccidia populations.

Quantitative Data

• Dose: 1 g/ton (1 ppm)
• Withdrawal: 0 Days

Relationships

• Target Diseases: Coccidiosis (Eimeria species).
• Drug Interactions: Alters the clearance rate of doxycycline (and other tetracyclines), requiring extended withdrawal periods for those antibiotics.
• Resistance: Susceptible to resistance under continuous long-term use, requiring shuttle and rotation programs.